Scientists have intensely focused on finding out how calorie restriction so radically extends life span. In response to reduced calorie intake, beneficial “youth” genes are activated while detrimental “senescence” genes are disabled. These favorable gene expression changes play a critical role in the ability of calorie restriction to slow aging.
The good news is that a select group of nutrients has been discovered that trigger many of the same favorable mechanisms (including more youthful gene expression patterns) as caloric restriction. Among the most promising caloric restriction mimics and enhancers are resveratrol, pterostilbene, quercetin, and grape seed polyphenols, along with black tea extract. These nutrients have been shown to generate many of the same effects in the body as caloric restriction, without significant dietary modification.1-8 In particular, they help mimic caloric restriction’s favorable impact on genes that influence the aging process.1-8
Calorie Restriction Mimetic Formula includes resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract to provide even broader spectrum gene expression support in one nutritional compound.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
. . . Click for more information on Calorie Restriction Mimetic Formula . . .
Reprinted with permission of Life Extension®. Visit www.LEF.org
http://www.lef.org/Vitamins-Supplements/Item01419/Calorie-Restriction-Mimetic-Formula.html
References
- Cell. 2006 Dec 15;127(6):1109-22.
- Endocrinology. 2008 Jan;149(1):84-92.
- Crit Care Med. 2004 Oct;32(10):2097-103.
- J Agric Food Chem. 1999 Apr;47(4):1416-21.
- Arch Pharm Res. 2002 Oct;25(5):561-71.
- Nutr Cancer. 1999;35(1):80-6.
- Anticancer Agents Med Chem. 2006 Sep;6(5):389-406.
- Nature. 2006 Nov 16;444(7117):337-42.
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