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Optimized Saffron with Satiereal

Written on July 26, 2010 by admin in Weight Management

Helps Support Healthy Eating Habits and Positive Mental Outlook

Satiereal® is a clinically studied, proprietary extract of saffron. You know saffron as a spice. What you may not know is that it has been prized in traditional cultures since ancient Persia as a way to enhance mood and relieve stress.1,2

Previously available only in Europe, this standardized saffron extract provides support for healthy body weight by targeting some of the emotional factors that make you eat more when you’re trying to eat less. The suggested daily serving of just two 88.25 mg capsules of new Optimized Saffron with Satiereal® delivers the active constituents safranal and crocin. These compounds have been shown to modulate certain serotonergic receptors in the brain to support mood.3-6 In clinical studies,7,8 women taking Satiereal® experienced …

1. 100% reduction in the desire to snack

2. 50% fewer instances of eating between meals

3. Less hunger

4. Moderate weight loss

5. More energy

6. Better mood

In fact, they reported feeling better about themselves and better in general. The result was a greater sense of control over between-meal snacking, and a change in eating behavior, without that “jittery feeling” or other undesirable effects.8

The same can happen for you. No more “grazing.” No more midnight “kitchen raids.”

Strengthen your resolve. Let Optimized Saffron with Satiereal® help you break the cycle of eating more than you want to—and eat what you want, when you want.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Click for more information on Optimized Saffron with Satiereal

Reprinted with permission of Life Extension®. Visit www.LEF.org

http://www.lef.org/Vitamins-Supplements/Item01432/Optimized-Saffron-with-Satiereal.html

References

1. Food in Medieval Times. Greenwood Publishing; 2004.

2. Saffron (Crocus sativus) Production and Processing. Science Publishers; 2006.

3. Hum Reprod. 1997 Jun;12(6):1142-51.

4. BMC Complement Altern Med. 2004 Sep 2;4:12.

5. J Ethnopharmacol. 2005 Feb 28;97(2):281-4.

6. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):439-42.

7. Nutraveris; 2006. Unpublished study.

8. In press. 2010.

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CR Mimetic Longevity Formula – Supports Healthy Metabolic Function

Written on July 14, 2010 by admin in Weight Management

In 2003, the Life Extension Foundation® introduced a standardized extract of resveratrol, a natural compound shown to favorably alter genes implicated in the aging process—many of the same genes that respond to calorie restriction or CR. In 2009, we introduced pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your “longevity genes.”

This year, we advanced the field even further, bringing together the 5 known calorie restriction mimetics in a single, high potency formula: resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract.1-8 Now we announce the latest innovation in the science of longevity with new CR Mimetic Longevity Formula featuring fisetin. This little-known flavonoid is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction9—without significant dietary modification. In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.10

Life Extension® has gone to extraordinary lengths to identify compounds that simulate calorie restriction’s ability to trigger youthful gene expression—the process by which genes transmit signals that slow certain aspects of aging. For example, previous research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals. A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent “longevity gene” activators that work in synergy with resveratrol.

Most abundant in strawberries, fisetin has the power to “switch on” powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.9 It also supports aging neurons in the presence of oxidative stress.11-13 Each serving of the new CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction’s favorable influence on your longevity genes. Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown10 and extending its effects.

This new formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources.

. . . Click for more information on CR Mimetic Longevity Formula . . .

Reprinted with permission of Life Extension®. Visit www.LEF.org

http://www.lef.org/Vitamins-Supplements/Item01419/Calorie-Restriction-Mimetic-Formula.html

References

1. Cell. 2006 Dec 15;127(6):1109-22.
2. Endocrinology. 2008 Jan;149(1):84-92.
3. Food Chem Toxicol. 2008 Apr;46(4):1320-6
4. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S62-70.
5. Cytokine. 2009 Aug;47(2):137-42
6. Nutr Cancer. 1999;35(1):80-6.
7. Anticancer Agents Med Chem. 2006 Sep;6(5):389-406.
8. Nature. 2006 Nov 16;444(7117):337-42.
9. Nature. 2004 Aug 5;430(7000):686-9.
10. Xenobiotica. 2000 Sep;30(9):857-66
11. Genes Nutr. 2009 Sep 10.
12. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73.
13. Brain Res. 2007 Oct 10;1173:117-25.

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SAMe – Supports Healthy Bones, Joints, and Emotional Well-Being

Written on June 8, 2010 by admin in Special Purpose

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

Methylation (contributing methyl groups to activate certain molecules)16,17
The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)18-20
Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)21-23

SAMe occurs naturally in the body; it is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.24 SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.

SAMe levels may become depleted from sickness and age. Supplementation of the co-factors — folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe — appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.16,17,19,22-23,25

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Their findings show the efficacy of SAMe in helping maintain stable mood and joint function, without any side effects.26 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.18,27-32 In addition, SAMe has multi-modal mechanisms of action that are used throughout the body, and especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage.

. . . Click for more information on SAMe . . .

Reprinted with permission of Life Extension®. Visit www.LEF.org

http://www.lef.org/Vitamins-Supplements/Item01055/SAMe-S-adenosylmethionine.html

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Health Nutrients Supporting Healthy Living

Optimized Saffron with Satiereal

CR Mimetic Longevity Formula – Supports Healthy Metabolic Function

SAMe – Supports Healthy Bones, Joints, and Emotional Well-Being